St John's Wort | Buy St John's Wort - Quest 333mg 90 tablets

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	Good for:  Depression, Anxiety
	Things to be aware of:  Can very rarely cause photosensitivity, dizzziness, tiredness, may also interact with some prescribed medicines so please check with your GP or practitioner.  p&p from £2.50+VAT no matter how much you buy!

St John's Wort

Also known as: hypericum, Klamath weed, goat weed

St. John's wort is used to help with depression, anxiety, and sleep disorders.

Researchers suggest that St John's wort inhibits the synaptosomal uptake of serotonin, dopamine and noradrenaline (norepinephrine) with approximately equal affinity. However, other in vitro binding assays carried out using St John's wort extract demonstrated significant affinity for adenosine, GABA(A), GABA(B) and glutamate receptors. In vivo St John's wort extract leads to a downregulation of beta-adrenergic receptors and an upregulation of serotonin 5-HT(2) receptors in the rat frontal cortex and causes changes in neurotransmitter concentrations in brain areas that are implicated in depression.

Recent neuroendocrine studies suggest that St John's wort is involved in the regulation of genes that control hypothalamic-pituitary-adrenal axis function. With regard to the antidepressant effects of St John's wort extract, many of the pharmacological activities appear to be attributable to the naphthodianthrone hypericin, the phloroglucinol derivative hyperforin and several flavonoids.

Nutritional Information

• St Johns Wort Extract      333mg 
• Providing Hypericin         1000µg 
• Equivalent to 2000mg of herb powder  

Additional Ingredients:
Di-Calcium Phosphate, Microcrystalline Cellulose, Magnesium Sterate, Glazing Agent: Hydroxypropylmethylcellulose.

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Dosage

Directions: One to three tablets daily with food

Suitable for Vegetarians and Vegans

Warning: May not be suitable for pregnant women.

Before taking this product please check with your doctor or pharmacist if you are taking any prescribed medicines, as St. John's Wort may affect the way they work.

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Does it work?

There have been a number of studies which are inconclusive however, in this fairly large study, involving a double-blind, randomized, placebo-controlled trial with 375 patients the authors investigated the antidepressant efficacy and safety of 300 mg t.i.d. of St John's Wort, (hydroalcoholic Hypericum perforatum extract WS 5570). RESULTS: Compared to placebo, WS 5570 produced a significantly greater reduction in total score on the Hamilton depression scale and significantly more patients with treatment response or remission. It was more effective in patients with higher baseline Hamilton scores and led to global reduction of depression-related core symptoms, assessed with the melancholia subscale of the Hamilton scale. The placebo and WS 5570 groups had comparable adverse events. CONCLUSIONS: H. perforatum extract WS 5570 was found to be safe and more effective than placebo for the treatment of mild to moderate depression.

Source - Efficacy of St. John’s Wort Extract WS 5570 in Major Depression: A Double-Blind, Placebo-Controlled Trial - Y. Lecrubier, M.D., G. Clerc, M.D., R. Didi, M.D., and M. Kieser, Ph.D. Full article - http://www.hbcprotocols.com/sjw-trial.html 

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