TumBiotix | Buy TumBiotix 30 capsule pack Triple pack offer

	Good for: Abdominal cramps, normalisation of stool frequency, diarrhoea
	Things to be aware of: No adverse affects known shipping from £2.50+VAT no matter how much you buy!

TumBiotix

TumBiotix is the trade name for a new formulation by the makers of our Lactobacillus plantarum Lp299v which combines Lp299v with Lactobacillus acidophilus. In combinatio these strains have been shown to reduce abdominal pain associated with IBS compared to placebo controls (see below for further details).

Purpose of formula

• Safe, natural support for the management of IBS.
• Promotes healthy bowel function and regularity.
• Probiotic bacteria prevent potentially harmful bacteria from establishing in the gut.
• Probiotic bacteria reinforce the intestinal lining, preventing harmful bacteria from crossing into the blood stream.
• Probiotic bacteria produce anti-microbial substances and beneficial short-chain fatty acids (SCFAs) which have been used clinically to treat inflammatory diseases of the colon.

Formula Features

• A clinically established combination of the probiotic strains L.plantarum and L.acidophilus.
• Non-dairy culture medium; suitable for vegetarians and vegans.

Lactobacillus plantarum 299v has the ability to temporarily colonise the human intestine and is highly resistant to stomach acid. It works by producing a barrier along the lining of the intestine which prevents the adhesion of pathogenic bacteria. It also helps produce short chain fatty acids that are used by the intestinal cells as food.

Supplemental use of Lactobacillus plantarum 299v has been shown to decrease IBS symptoms by up to 95%. Lactobacillus plantarum 299v has also been shown to help boost the immune system, maintain the health of the heart and reduce the incidence of non-IBS related diarrhoea.

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Dosage

Take one or two capsules daily with food, swallow with water

Nutritional Information
One capsule provides: Lactobacilli Culture 50 mg, typically providing 2 billion Lactobacillus Acidophilus / Lactobacillus Plantarum

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Does it work?

Support for L.plantarum and L.acidophilus includes: Probiotics in the treatment of Irritable
Bowel Syndrome. Saggioro A (2004) J Clin Gastroenterol.38(6Suppl):S104-6

Seventy IBS patients were randomly assigned to receive for 4 weeks either an active preparation containing Lactobacillus plantarum LP 01 and Bifidobacterium breve BR 03 or Lactobacillus plantarum LP 01 and Lactobacillus acidophilus LA 02 (all strains at
concentrations of 5 x 10(9)) or equivalent placebo powder. Pain score in different abdominal locations after treatment decreased in probiotics groups A and B 42% and 49% versus 25% (P < 0.05) in placebo group after 14 days and 45% and 49% versus 29.5% (P < 0.001) after 28 days. The severity score of characteristic IBD symptoms significantly decreased in probiotic groups A and B versus placebo group after 14 days, 49.3% and 55.6% versus 8% (P < 0.001), and these data were confirmed after 28 days (56% and 55.6% versus 14.4% P < 0.001). In conclusion, short-term therapy with probiotics may be considered a promising approach for IBS therapy.

Support for L.plantarum includes:
Alteration of Intestinal Microflora is associated with reduction in abdominal bloating and pain in patients with Irritable Bowel Syndrome. Nobaek et al (2000) Am J Gastroenterology 95(5):1231-1238

Forty patients were randomized to receive either LP299V in liquid suspension (20 patients) or placebo (20 patients) over a period of 4 weeks. Clinical examination was performed at baseline and at the end of the study. Additionally, patients assessed their symptoms by applying a scoring system. All patients treated with LP299Vreported resolution of their abdominal pain as compared to 11 patients from a placebo group (P = 0.0012).

There was also a trend towards normalization of stool frequency in constipated patients in six out of 10 patients treated with LP299V compared with two out of 11 treated with placebo (P = 0.17). With regard to all IBS symptoms an improvement was noted in 95% of patients in the LP299V group vs 15% of patients in the placebo group (P < 0.0001). LP299V seems to have a beneficial effect in patients with IBS.

A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum in patients with Irritable Bowel Syndrome. Niedzielin et al (2001) Eur J Gastroenterol Hepatol.13: 1143-1147

60 patients with IBS were randomized into two groups, one receiving 400 ml per day of a rose-hip drink containing 5 x 10(7) cfu/ml of Lactobacillus plantarum (DSM 9843) and 0.009 g/ml oat flour, and the other group receiving an equivalent plain rose-hip drink, for 4 wk. The patients recorded their own GI function, starting 2 wk before the study and continuing throughout the study period. Twelve months after the end of the study all patients were asked to complete the same questionnaire regarding their symptomatology as at the start of the study. All patients tolerated the products well. The patients receiving Lb. plantarum had these bacteria on rectal biopsies. Flatulence was rapidly and significantly reduced in the test group compared with the placebo group (number of days with abundant gas production, test group 6.5 before, 3.1 after vs 7.4 before and 5.6 after for the placebo group). Abdominal pain was reduced in both groups. At the 12-month follow-up, patients in
the test group maintained a better overall GI function than control patients. Fifty-nine percent of the test group patients had a continuous intake of fermented products, whereas the corresponding figure for the control patients was 73%. The fiber content of the test solution was minimal and it is unlikely that the fiber content could have had any effect.

Further information

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